After posting the original box art for Resident Evil 5, Capcom have confirmed that it has indeed changed.
“It has been brought to our attention that the recently issued packaging for the Limited Edition version of Resident Evil 5 on Xbox 360 contains an error. It wrongly stated that the game supported 2-16 players via system link. The correct number of players supported via system link is in fact two. Please accept our apologies for this mistake and any confusion this may have caused.” said a Capcom spokesperson to Strategy Informer.