Aside from Two Point Hospital, also playable at TwitchCon 2018 will be various Total War titles, and the latest Total War: Warhammer 2 expansion: Curse of the Vampire Coast.
While there's been no word on what, exactly, are SEGA and Two Point Studios preparing for the show, it's going to be something special: "Two Point Hospital will be in attendance at TwitchCon, with a top-secret announcement set to be revealed at the show. Whether you’re new to the game or a loyal hospital administrator, you’ll be interested to hear what they have to say."
If you're more interested in SEGA's Total War offerings, however, you can look forward to playable builds of Curse of the Vampire Coast and Total War: Three Kingdoms, with special setpieces already prepared for the spectacle.
TwitchCon 2018 will be streamed on Twitch, naturally, but if you want to enjoy all these announcements live, you're going to have to get a ticket and make your way to San Jose, California on 26th to 28th of October, so don't dawdle.